3-Methylmethcathinone

Please note, this OEL/ADE monograph also applies to mephedrone (CAS RN 1189805-46-6) and 2-methylmethcathinone hydrochloride (CAS RN 1246815-51-9). 3-Methylmethcathinone (3-MMC, also known as metaphedrone) is a synthetic cathinone and has become one of the most popular recreational drugs worldwide to replace mephedrone (4-methylmethcathinone or 4-MMC). No evidence has been found that 3-MMC has been therapeutically used. 3-Methylmethcathionine (3-MMC) is legally controlled in many countries but is still easily available for purchase from websites and is frequently found in recreational-drug settings. Cathinone is a naturally occurring β-ketone analog of amphetamine found in the leaves of the “khat” plant (Catha edulis) consumed recreationally in the Arabian Peninsula and northeast Africa. Methcathinone is sold as “bath salts” and labeled “not for human consumption”. Bupropion is the only cathinone derivative used medically in the US and Europe. Chemically, synthetic cathinones are analogues of the natural cathinone, which in turn is closely related to amphetamines, with the addition of a ketone group at the β- position of the amino alkyl chain, which is attached to the phenyl ring. The effects of 3-MMC are commonly regarded as extremely stimulating and energetic. It is sometimes used during activities such as running, climbing and dancing.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

3-Methylmethcathinone

CAS Registry Number:
1246816-62-5
Synonyms:
3-MMC, metaphedrone
Cost:
$639 USD

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Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. 10-12 pages in length, with calculations and cited references.
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