Please note, this OEL/ADE monograph also applies to acalabrutinib maleate (CAS RN 2242394-65-4). Acalabrutinib is a kinase inhibitor indicated for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one other chemotherapy medication. Acalabrutinib inhibits of Bruton’s tyrosine kinase (BTK) and prevents the activation of the Bcell antigen receptor (BCR) signaling pathway. This prevents B-cell activation and BTKmediated activation of downstream survival pathways. This inhibits the growth of malignant B cells that overexpress BTK, which is overexpressed in malignancies and is important to B lymphocyte development, activation, signaling, proliferation, and Ribociclibsurvival.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Acalabrutinib, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.