Please note, this OEL/ADE monograph also applies to Acepromazine maleate (CAS RN 3598-37-6). Acepromazine maleate is a phenothiazine derivative that is used as a neuroleptic agent in veterinary medicine. Acepromazine injection in dogs and cats can be used as an aid in controlling intractable animals during examination, treatment, grooming, x-ray and minor surgical procedures, to alleviate itching as a result of skin irritation and as an antiemetic to control vomiting associated with motion sickness. It is particularly useful as a preanesthetic agent to enhance and prolong the effects of barbiturates, thus reducing the requirements for general anesthesia and as an adjunct to surgery under local anesthesia. In horses, acepromazine injection can be used as an aid in controlling fractious animals during examination, treatment, loading and transportation. Particularly useful when used in conjunction with local anesthesia for firing, castration, neurectomy, removal of skin tumors, ocular surgery and applying casts.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.