Please note, this OEL/ADE monograph also applies to ademetionine butanedisulfonate (CAS RN 200393-05-1) and ademetionine tosylate bis(sulfate) (CAS RN 97540-22-2). Ademetionine, also known as S-Adenosylmethionine (SAMe), is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. Ademetionine is used as a drug in many European countries for the treatment of adults with intrahepatic cholestasis in pre-cirrhotic and cirrhotic states, intrahepatic cholestasis in pregnancy and for the treatment of depressive symptoms. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well-being.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Ademetionine, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.