Please note, this OEL/ADE monograph also applies to almitrine bismesylate (CAS RN 29608-49-9). Almitrine, as almitrine bismesylate, is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. It is indicated as an adjuvant treatment with mechanical ventilation in the most severe cases of acute respiratory distress syndrome (ARDS) with refractory hypoxemia and hypercapnia despite optimized artificial respiratory assistance (protective ventilation, prone position, etc.) and / or in the absence other accessible respiratory supply device (i.e., CO2 purification, venous oxygenation).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Almitrine, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.