Alpha Olefin Sulfonates

Alpha olefin sulfonates (AOS) have been used successfully for many years in laundry and personal care products throughout Asia. The sodium salts of AOS have been used for many years as anionic surfactants in a variety of industrial, personal care, and household cleaning applications. Beneficial attributes of AOS include good cleaning and foaming properties in both soft and hard water, mildness to skin, and rapid biodegradability. Household applications include laundry and dish detergents, and personal care applications include shampoos and liquid hand soaps. In Asia, particularly Japan and Korea, AOS have commonly been used in laundry powders. Sodium C14-16 olefin sulfonate, sodium C12-14 olefin sulfonate, sodium C14-18 olefin sulfonate, and sodium C16-18 olefin sulfonate are utilized in cosmetics as surfactant-cleansing agents. These compounds, known as sodium α-olefin sulfonates (AOS), belong to the category of anionic surfactants featuring hydrophobic and hydrophilic (polar) components within their molecular structure. Commercial mixtures encompass a variety of isomers and homologs of related compounds, exhibiting diverse physicochemical properties tailored to different applications. Alpha olefin sulfonates (AOS), derived from the sulfonation of alpha-olefins, are nonvolatile substances consisting of two components, sodium alkene sulfonate and hydroxy alkane sulfonate, characterized by alkyl chain lengths ranging from C14 to C18.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Alpha Olefin Sulfonates

CAS Registry Number:
Trade names:
Hansanyl OS®, Ifrapon AOS®, Superfoam®,
$679 USD


Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. Over 20 pages in length, with calculations and cited references.
  • Save time! Unsurpassed delivery with instant download.
  • Save money. Similar documents cost 5-12 times as much.
  • Stay current. Automatic notification of revisions.

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  • K. Rosenthal
  • Director of Manufacturing