Please note, this OEL/ADE monograph also applies to amiloride hydrochloride anhydrous (CAS RN 2016-88-8) and amiloride hydrochloride dihydrate (CAS RN 17440-83-4). Amiloride is indicated for the treatment of high blood pressure and congestive heart failure. Amiloride hydrochloride is a pyrazine-carbonyl-guanidine that exhibits potassium sparing diuresis activity with weak sodium sparing, diuretic and antihypertensive properties. It blocks the reabsorption of sodium at the distal convoluted tubule, cortical collecting tubule, and collecting duct, resulting in reduced net negative potential of the tubular lumen and decreased secretion and subsequent excretion of hydrogen and potassium. Amiloride hydrochloride does not inhibit aldosterone and its action manifests even without aldosterone.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Amiloride, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.