Please note, this OEL/ADE monograph also applies to angiotensin II acetate (CAS RN 68521-88-0). Angiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock. Angiotensin II is part of the renin-angiotensin-aldosterone (RAAS) system. It raises blood pressure by vasoconstriction, increases aldosterone release from the adrenal glands and sodium and water reabsorption from the proximal tubular cells, and increases vasopressin secretion. Direct action of angiotensin II on the vessel wall is mediated by binding of the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Angiotensin II, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.