Apitoxin or bee venom is made by bees. This is the poison that makes bee stings painful. Bees are insects from the Hymenoptera order, which includes wasps. Therefore, bee venom contains some of the same compounds as wasp venom. Bee venom is used for therapeutic purposes. Giving repeated and controlled injections of bee venom under the skin (the subcutaneous (SC) route of administration) causes the immune system to get used to bee venom and helps reduce the severity of an allergy to bee venom. Bee venom immunotherapy provides 98% to 99% protection from reactions to bee stings. Once immunotherapy is stopped, the risk of reaction over the next 5 to 10 years is about 5% to 15%. Purified bee venom for under-the-skin injection is a United States (US) Food and Drug Administration (FDA) approved product. The bee species predominantly responsible for human envenoming are Apis mellifera mellifera (A. m. mellifera), A. m. ligustica, and A. m. scutellata in Africa.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Apitoxin, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.