Benazepril, a prodrug for benazeprilat, is indicated to treat high blood pressure. Benazepril hydrochloride (prodrug) is cleaved by the liver to form its active drug benazeprilat, which is a more potent non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor. ACE inhibition prevents the conversion of angiotensin I to angiotensin II, resulting in decreased angiotensin II with subsequent decrease in vasopressor activity and aldosterone secretion, and increase in serum potassium levels. Its antihypertensive action is believed to be primarily due to suppression of renin-angiotensin-aldosterone system.
This 10 page OEL/ADE monograph covers both Benazepril and Benazepril HCl (CAS RN 86541-74-4).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.