Please note, this OEL/ADE monograph also applies to benserazide hydrochloride (CAS RN 14919-77-8). Benserazide is a peripheral decarboxylase inhibitor indicated for the treatment of Parkinson’s disease in combination with levodopa. Benserazide, a peripheral decarboxylase inhibitor, blocks the decarboxylation of levodopa, the metabolic precursor of dopamine. Dopamine is depleted in the brain of Parkinson’s patients. Benserazide is hydroxylated to trihydroxybenzylhydrazine in the intestinal mucosa and the liver. It is a potent inhibitor of the aromatic amino acid decarboxylase and protects levodopa from decarboxylation to dopamine in the intestine, before it passes the bloodbrain barrier. Benserazide also inhibits other peripheral enzymes, but is significantly more specific to decarboxylase. Administration of benserazide with levodopa allows levodopa to exert its primary action in the central nervous system (CNS), rather than in peripheral tissue, which can cause adverse effects including nausea, vomiting, and cardiac arrhythmias. No other pharmacodynamic effects of benserazide, other than decarboxylase inhibition, have been reported.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Benserazide, just click the ADD TO CART button.
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