Benzonatate is indicated for cough. Suppresses cough through a peripheral action, anesthetizing the stretch or cough receptors of vagal afferent fibers, which are located in the respiratory passages, lungs, and pleura; also, may suppress transmission of the cough reflex by a central mechanism, at the level of the medulla. Benzonatate suppresses cough through a peripheral action, anesthetizing the stretch or cough receptors of vagal afferent fibers, which are located in the respiratory passages, lungs, and pleura. Benzonatate suppress transmission of the cough reflex by a central mechanism, at the level of the medulla in the brain. When applied locally, benzonatate has anesthetic effects by binding within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability. Unlike narcotics, benzonatate has no inhibitory effects on the respiratory center.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.