Betamethasone valerate (the 17-valerate derivative of betamethasone) is a topical synthetic adrenocorticosteroid indicated for the relief of the inflammatory and itching (pruritic) manifestations of corticosteroid-responsive skin diseases (dermatoses). Betamethasone valerate, an analog of prednisolone, is a moderately potent to potent synthetic adrenocortical topical steroid with a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. Its potency is expressed as betamethasone. Like other topical corticosteroids, betamethasone valerate has anti-inflammatory, antipruritic, and vasoconstrictive properties.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.