Biotin is a water-soluble, enzyme co-factor present in minute amounts in every living cell. Biotin is a vitamin, a coenzyme and a growth factor used for many different functions including hair loss, nerve disorders, vitamin deficiency, brittle nails, cancer, diabetes, and enzyme disorders. Biotin is a water-soluble member of the vitamin B group and was first isolated from egg yolk as an enzymatic yeast-growth factor. It is identical to coenzyme R (Rhizobium growth factor) and pharmacologically it is considered to be a carbonic acid-fixation coenzyme. Biotin affects gene expression by reacting with and binding covalently to histones in the nuclei of cells. The vitamin regulates synthesis of the enzyme that phosphorylates sugar, the actions of which are highly specific to glucose. Biotin also may be highly involved in glucose metabolism and biotin deficiency appears probable in patients on chronic hemodialysis. Biotin concentration influences lipid metabolism in humans. The vitamin has demonstrated inhibition of freeradical generation.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Biotin, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.