Buspirone is an anxiolytic agent and serotonin receptor agonist indicated to treat anxiety disorders or the short-term relief of symptoms of anxiety. Buspirone hydrochloride is an anxiolytic agent with a high affinity for 5-HT1A serotonin receptors, moderate affinity for dopamine type 2 (DA2) receptors, and no significant affinity for benzodiazepine receptors. It has no effect on GABA binding. The mechanism of action of buspirone is not fully elucidated. Buspirone acts as an agonist for the 5-HT1A receptors, and both an antagonist and agonist for DA2 receptors. The net result is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Buspirone, just click the ADD TO CART button.
If you're wondering about HBEL, we have something for you.
Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.