Carbazochrome sodium sulfate is indicated for use as a hemostatic agent and has been used in the treatment of hemorrhoids. It has also been used for frostbite due to decreased peripheral vascular resistance and many other indications requiring a hemostatic effect. The mechanism of action of carbazochrome sodium sulfate is unknown, but it may modulate fibrinolysis through alteration of endothelial cell function. It is an antihemorrhagic, or hemostatic agent, that is thought to cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. Carbazochrome sodium sulfate has a capillary stabilizing action on endothelial barrier dysfunction that may be induced by a variety of vasoactive substances or agents that increase the vascular permeability. It also reduces the vascular hyperpermeability induced by a variety of vasoactive agents through inhibition of agonist-induced phosphoinositide hydrolysis.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.