Castor oil is a fixed oil obtained from seeds of the Ricinus communis plant. It is a stimulant laxative indicated for the treatment of constipation and may also be used as a purgative. Within the small intestine, pancreatic lipases hydrolyze castor oil to glycerol and ricinoleic acid, which are responsible for its laxative effects. Ricinoleate reduces net absorption of fluid and electrolytes and stimulates intestinal peristalsis.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API).
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
The OEL monograph for Castor Oil is under development.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.