Please note, this OEL/ADE monograph also applies to chloral hydrate (CAS RN 302-17-0) and chloral betaine (CAS RN 2218-68-0). Chloral (also known as trichloroacetaldehyde) is an organochlorine compound that consists of acetaldehyde, where all the methyl hydrogens are replaced by chloro groups. It has a role as a mouse metabolite. It is an organochlorine compound and an aldehyde. Chloral hydrate is a synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. It is indicated mainly as a hypnotic in the treatment of insomnia. However, it is only effective as a hypnotic for short-term use. It may be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex. Externally, chloral hydrate has a rubefacient action and has been also used as a counterirritant.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Chloral, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.