Chloroacetic Acid

Chloroacetic acid, also known as monochloroacetic acid (MCAA) is a chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent. It is a synthetic chemical not found in natural products. Monochloroacetic acid (MCAA) is produced by chlorination of acetic acid or hydrolysis of trichloroethylene using sulfuric acid. Monochloroacetic acid or its sodium salt, sodium monochloroacetate, are used primarily in the industrial production of carboxymethyl-cellulose, herbicides, and thioglycolic acid as well as in the production of plastics, pharmaceuticals, flavors, cosmetics, and other organic chemicals.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Chloroacetic Acid

CAS Registry Number:
79-11-8
Cost:
$639 USD

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Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. 10-12 pages in length, with calculations and cited references.
  • Save time! Unsurpassed delivery with instant download.
  • Save money. Similar documents cost 5-12 times as much.
  • Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Chloroacetic Acid, just click the ADD TO CART button.

HBEL

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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.
  • K. Rosenthal
  • Director of Manufacturing
  • Pharmatek Laboratories