Choline salicylate is a salicylic acid derivative used in the treatment of pain and fever, and in the management of rheumatic disorders. Choline salicylate is also used as a local analgesic. Solutions containing up to about 20% choline salicylate are used in ear disorders such as the relief of pain in otitis media and externa but are considered to be of doubtful value; they are also used to soften ear wax as an aid to removal. An 8.7% gel is used for lesions of the mouth. Choline salicylate has also been applied topically in a rubefacient preparation for the relief of muscular and rheumatic pain (3). Choline salicylate is also given in the form of choline magnesium trisalicylate.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.