Copper Gluconate

Copper gluconate is indicated for pesticide use in the United States, in dietary supplements as a readily assimilable form of copper, as oral deodorant, and as a feed additive. It is also used as a synergist and nutritional supplement for foods and for the prevention and treatment of copper deficiency. Copper-containing compounds are involved in oxidation-reduction reactions and react directly with molecular oxygen to produce reactive oxygen species. Copper gluconate is an orally bioavailable copper salt of D-gluconic acid that has a role as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase. Additionally, copper forms complexes with thiocarbamate disulfiram (DSF). The DSF-copper complexes enhance specific proteasome inhibition, which may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. Copper also plays a catalytic role in oxygendependent reactions and is also an integral part of metalloenzymes, including monoamine oxidase, cytochrome oxidase, superoxide dismutase, and more.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Copper Gluconate

CAS Registry Number:
527-09-3
Cost:
$639 USD

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Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. 10-12 pages in length, with calculations and cited references.
  • Save time! Unsurpassed delivery with instant download.
  • Save money. Similar documents cost 5-12 times as much.
  • Stay current. Automatic notification of revisions.

How to order

To order an OEL monograph for this compound, just click the ADD TO CART button.

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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.
  • K. Rosenthal
  • Director of Manufacturing
  • Pharmatek Laboratories