Please note, this OEL/ADE monograph also applies to alternate CAS RN 12427-33-7). Corticotropin is used to treat infantile spasms in infants and children under 2 years of age, to treat exacerbations of multiple sclerosis in adults, and for disease of joints/collagen/ skin, allergy, eye, respiration, and swelling. Corticotropin is a hormone produced by the body. Its mechanism of action to treat infantile spasms is not known. Corticotropin, also known as adrenocorticotropic hormone (ACTH) is produced by the pituitary gland and stimulates the adrenal gland to secrete cortisol.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.