Please note, this OEL/ADE monograph also applies to Dantrolene Sodium (CAS RN 14663-23-1). Dantrolene is indicated for the treatment of malignant hyperthermia and muscle spasticity. Dantrolene sodium induces skeletal muscle relaxation by directly affecting the contractile response. It is suggested that its interference with the release of calcium ions from the sarcoplasmic reticulum results in the dissociation of the excitation-contraction coupling in skeletal muscle.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Dantrolene, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.