Diamine oxidase (EC 22.214.171.124), also called histaminase, amiloride-binding protein, and amiloride-sensitive amine oxidase, is a copper-dependent amino oxidase encoded in humans by the AOC1 gene located on chromosome 7 (7q34-36). Diamine oxidase is a homodimer and ubiquitous enzyme with a molecular mass in the range of 140 to 200 kDa. The enzyme diamine oxidase, formerly known as histaminase, is naturally present in various tissues, with notably high activity in the intestinal mucosa. More precisely, diamine oxidase is abundantly found in the intestinal mucosa of humans and various other mammalian species. Diamine oxidase functions both as an endogenous enzyme within the body and as a frequently used nutritional supplement for addressing symptoms related to histamine intolerance (HIT). Diamine oxidase is frequently used as a nutritional supplement to treat disorders from histamine accumulation including migraines, fibromyalgia, bowel syndrome (IBS), atopic skin, or even attention deficit hyperactivity disorder (ADHD).
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Diamine Oxidase, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.