Diosmin is a natural bioflavinoid found in plant extracts including citrus fruits, marketed as a medical food in the US. It is indicated for the treatment of a variety of conditions related to vascular insufficiency and hemorrhoids. Diosmin acts by restoring normal metabolic aspects of chronic venous insufficiency including modulating venous tone and capillary resistance by increasing the sensitivity of vascular smooth muscle to norepinephrine and calcium. It also reduces venous valve damage by inhibiting interactions between white blood cells, decreasing capillary permeability, improving capillary resistance and increasing lymphatic drainage.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Diosmin, just click the ADD TO CART button.
If you're wondering about HBEL, we have something for you.
Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.