Disulfiram is used as a fungicide, industrial antioxidant and most commonly to aid in the treatment of enforced sobriety in select patients with alcoholism. Disulfiram has also been used as a chelator in cases of copper or nickel intoxication. Disulfiram (also known as tetraethylthiuram disulfide or (TETD)) blocks the oxidation of alcohol at the acetaldehyde stage. Acetaldehyde that is produced as a result of the process of oxidation of ethanol by alcohol dehydrogenase (ADH), ordinarily does not accumulate in the body because it is further oxidized, primarily by aldehyde dehydrogenase (ALDH) virtually as soon as it is formed. Following the administration of disulfiram, both cytosolic and mitochondrial forms are irreversibly inactivated to varying degrees causing the blood acetaldehyde to rise to 5-10 times above the level seen in patients ingesting ethanol without disulfiram.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Disulfiram, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.