Please note, this OEL/ADE monograph also applies to doxapram hydrochloride monohydrate (CAS RN 7081-53-0) and doxapram hydrochloride anhydrous (CAS RN 113-07-5). Doxapram is a respiratory stimulant with analeptic activity indicated for use as a temporary treatment in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease (COPD). Doxapram acts independent of oxygen levels and directly stimulates the peripheral carotid chemoreceptors, possibly by inhibiting the potassium channels of type I cells within the carotid body, which stimulates catecholamine release. This results in the prevention or reversal of respiratory depression.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Doxapram, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.