Droperidol is indicated to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures. The exact mechanism of action is unknown, but within the CNS, droperidol acts principally at subcortical levels and exhibits a strong sedative effect. The main actions appear to stem from its potent dopamine receptor antagonism with minor antagonistic effects on alpha-1 adrenergic receptors as well. It may antagonize the actions of glutamic acid within the extrapyramidal system and it may inhibit catecholamine receptors and the reuptake of neurotransmitters. Droperidol also inhibits sympathetic postganglionic alpha-adrenergic receptor binding sites; however, therapeutic dosages of droperidol do not appear to completely block these receptors. Droperidol has antiemetic activity, but does not appear to exhibit analgesic activity.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Droperidol, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.