Eflornithine hydrochloride is approved for reduction of unwanted facial hair (2). It has also been used for years as a treatment for trypanosomiasis. Eflornithine inhibits ornithine decarboxylase and the synthesis of polyamines which may be necessary for hair growth. Animal data indicate that inhibition of ornithine decarboxylase inhibits cell division and synthetic function which may affect hair growth. Trypanosomes may be more susceptible to eflornithine than mammals because of their slow turnover of ornithine decarboxylase.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL monograph for this compound, just click the ADD TO CART button.
If you're wondering about HBEL, we have something for you.
Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.