OEL Fastrac Catalog

Elafibranor is a multimodal and pluripotent medication under investigation for treatment of non-alcoholic fatty liver disease (NAFLD) including non-alcoholic steatohepatitis (NASH). Elafibranor is an agonist of the peroxisome proliferator-activated receptors (PPARs) α and δ. PPARs are nuclear receptors that play key roles in cellular processes regulating metabolic homeostasis, immune-inflammation, and differentiation. PPAR-α is most prominently expressed in the liver and controls the lipid flux in the liver by modulating fatty acid transport and improving plasma lipids. PPAR-δ (also called PPAR-β) regulates metabolism in liver and peripheral tissues. PPAR α and δ agonists enhance fatty acid transport and oxidation. Elafibranor enhances the activity of PPARs, which has a positive effect on obesity, insulin-resistance and diabetes, atherosclerosis, inflammation, and plasma lipids (increasing HDL, lowering triglycerides and LDL).

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

• The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
• A listing of all cited references utilized in the derivation of the OEL and ADE
• An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

• Fully documented. Over 20 pages in length, with calculations and cited references.
• Save time! Unsurpassed delivery with instant download.
• Save money. Similar documents cost 5-12 times as much.
• Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Elafibranor, just click the ADD TO CART button.

HBEL

If you're wondering about HBEL, we have something for you.