Please note, this OEL/ADE monograph also applies to eltrombopag olamine (CAS RN 496775-62-3). Eltrombopag is a thrombopoietin receptor agonist that stimulates platelet production in the bone marrow. It is indicated for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenia (ITP) and in patients with chronic hepatitis C to allow the initiation and maintenance of interferon-based therapy. It is also used in combination with standard immunosuppressive therapy in patients with severe aplastic anemia. Eltrombopag is an orally bioavailable, small-molecule thrombopoietin (TPO)-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells. Eltrombopag is a stimulator of STAT and JAK phosphorylation and does not activate the AKT pathway.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Eltrombopag, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.