Please note, this OEL/ADE monograph also applies to ephedrine hydrochloride (CAS RN 50-98-6), and ephedrine sulfate (CAS RN 134-72-5). Ephedrine is a mixed-acting oral sympathomimetic indicated for the treatment of asthma, drug induced low blood pressure, and the common cold. Ephedrine’s mechanism of action stems from stimulation of both alpha-adrenergic and betaadrenergic receptors. It exerts a direct effect on adrenergic receptors and an indirect action due to the release of norepinephrine. Ephedrine stimulates the central nervous system and increases blood pressure by vasoconstriction and increasing cardiac output. Stimulation of beta-adrenergic receptors in the lungs results in bronchodilation. Urinary retention occurs because of constriction of the sphincter muscle and relaxation of the urinary bladder wall. Pharmacologic actions of ephedrine include elevation of blood pressure, increased pulse rate, vasoconstriction and cardiac stimulation to increase output and force of contraction.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.


CAS Registry Number:
Brand names:
Asthmacon, Mudrane GG, Mudrane, Quelidrine, Primatene Dual Action
$639 USD


Why do you need this OEL Fastrac monograph?

OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:

  • The numerical OEL and control band assignment needed to determine the level of required engineering controls and personal protective equipment
  • A listing of all cited references utilized in the derivation of the OEL and ADE
  • An expert review and discussion with respect to the critical endpoints of concern, the rationale for the choice of endpoints, and dose that is to be used in the derivation of the ADE (PDE), as required by the EMA's Guideline on setting health-based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities

Benefits of OEL Fastrac monographs

  • Fully documented. 10-12 pages in length, with calculations and cited references.
  • Save time! Unsurpassed delivery with instant download.
  • Save money. Similar documents cost 5-12 times as much.
  • Stay current. Automatic notification of revisions.

How to order

To order an OEL/ADE monograph for Ephedrine, just click the ADD TO CART button.


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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.
  • K. Rosenthal
  • Director of Manufacturing
  • Pharmatek Laboratories