OEL Fastrac New and updated OEL Fastrac monographs from Affygility Solutions https://affygility.com/oel/ en Copyright © Affygility Solutions oelfastrac@affygility.com https://affygility.com/apple-touch-icon-oel-fastrac.png OEL Fastrac https://affygility.com/oel/ N,N-Dimethyl-5-Methoxytryptamine https://affygility.com/oel/n,n-dimethyl-5-methoxytryptamine.html Thu, 16 Jul 2026 09:46:37 -0600 oel-fastrac-79492618 Affygility Solutions Please note, this OEL/ADE monograph also applies to Mebufotenin benzoate/5-methoxy DMT benzoate (CAS RN 282103-25-7), 5-Methoxy DMT oxalate (CAS RN 17286-40-7). N,N-Dimethyl-5-methoxytryptamine (5-MeO-DMT), also known as Omethylbufotenine, methylbufotenine, and mebufotenin, is a tryptamine alkaloid that is N,N-dimethyltryptamine (DMT) substituted by a methoxy group at position 5. N,NDimethyl- 5-methoxytryptamine (5-MeO-DMT) is a naturally occurring tryptamine and was first chemically synthesized and later isolated from the bark of the tree (Dictyoloma incanescens). It is also found in a variety of plants, fungi, toads, and mammals. N,NDimethyl- 5-methoxytryptamine (5-MeO-DMT) is the major psychoactive compound of the toxic secretion of Colorado River Bufo alvarius toads. It has been used as an entheogen in ceremonies by indigenous people in Latin America.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for N,N-Dimethyl-5-Methoxytryptamine is available for purchase for $989 USD.

]]> Vanillyl Butyl Ether https://affygility.com/oel/vanillyl-butyl-ether.html Thu, 16 Jul 2026 09:46:34 -0600 oel-fastrac-79492617 Affygility Solutions Vanillyl butyl ether, also known as butyl vanillyl ether, vanillylbutyl ether or hotact VBE, is an ether of monohydroxybenzoic acid. It has a characteristic trigeminal, burning, hot pepper nature and can be used in spice flavors like pepper, cinnamon, and ginger. It is added to food products as a flavoring agent. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Vanillyl Butyl Ether is available for purchase for $989 USD.

]]> Mexazolam https://affygility.com/oel/mexazolam.html Mon, 13 Jul 2026 08:14:17 -0600 oel-fastrac-79492132 Affygility Solutions Mexazolam (CS-386) is a long-acting benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions. It is also indicated for tension, depression, easy fatigability, and obsessive-compulsive, phobic, and sleep disorders associated with neurosis. Benzodiazepines are only indicated when these situations are serious, disabling, or cause a marked state of suffering.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Mexazolam is available for purchase for $989 USD.

]]> Estradiol Cypionate https://affygility.com/oel/estradiol-cypionate.html Mon, 13 Jul 2026 08:14:14 -0600 oel-fastrac-79492131 Affygility Solutions Estradiol cypionate is a prodrug ester of estradiol, a naturally occurring hormone that circulates endogenously in the human body. Estradiol is the most potent form of estrogen in mammals and acts as the major female sex hormone. Estradiol cypionate is used to treat vasomotor symptoms and hypoestrogenism due to hypogonadism.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Estradiol Cypionate is available for purchase for $989 USD.

]]> Acetaldehyde https://affygility.com/oel/acetaldehyde.html Mon, 13 Jul 2026 08:14:12 -0600 oel-fastrac-79492130 Affygility Solutions Acetaldehyde is a clear, colorless, highly volatile liquid occurring widely in nature and found in various plants, ripe fruits, vegetables, cigarette smoke, and gasoline and diesel exhaust. Acetaldehyde is used as an intermediate in the production of acetic acid and several esters, in the manufacture of disinfectants, drugs, perfumes, explosives, lacquers, varnishes, photographic chemicals, phenolic and urea resins, rubber accelerators and antioxidants, and room air deodorizers, and as a synthetic flavoring substance, food preservative, and fragrance.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Acetaldehyde is available for purchase for $989 USD.

]]> Eugenol https://affygility.com/oel/eugenol.html Thu, 09 Jul 2026 09:48:32 -0600 oel-fastrac-79491362 Affygility Solutions Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Eugenol is an ingredient in oral hygiene preparations and has been used as a flavor and food additive. Eugenol is also used as a pesticide. Eugenol is the major constituent (70% to 90%) in the aromatic oil extract from cloves (Syzygium aromaticum), a spice widely used as a flavoring for meats, stews, cakes, and teas. Eugenol is also found in lower concentrations in cinnamon and other aromatic spices.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Eugenol is available for purchase for $989 USD.

]]> Hexanal https://affygility.com/oel/hexanal.html Thu, 09 Jul 2026 09:48:30 -0600 oel-fastrac-79491361 Affygility Solutions Hexanal, also known as aldehyde C-6, caproaldehyde, caproic aldehyde, hexaldehyde, and hexoic aldehyde, is an n-alkanal, a saturated fatty aldehyde, and a medium-chain fatty aldehyde. It is naturally produced by the body (endogenous) (1, 3). Hexanal is a naturally occurring bioactive volatile compound found in plants associated with the smell of foliage and grass. Hexanal is used as a flavoring agent, as a food additive, and in perfumery (at low concentrations) for obtaining fruity notes and in organic synthesis of plasticizers, rubber chemicals, dyes, synthetic resins, and insecticides.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Hexanal is available for purchase for $989 USD.

]]> Pentanal https://affygility.com/oel/pentanal.html Thu, 09 Jul 2026 09:48:28 -0600 oel-fastrac-79491360 Affygility Solutions Pentanal, also known as n-valeraldehyde, is an aldehyde mainly used as a chemical intermediate in the production of valeric acid and amyl alcohol, as a polymer modifier and as a rubber accelerator. Pentanal is also used extensively as a natural and synthetic flavoring agent. Pentanal is occasionally a minor ingredient in some cosmetic products like perfumes. Pentanal is a component (at 0.05% to 0.07%) of rose oil, which is used as a fragrance ingredient in cosmetics, toilet waters, and perfumes and as a flavoring for foods and tobacco products, particularly chewing tobacco.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value and the Permitted Daily Exposure (PDE) value.

The OEL Fastrac monograph for Pentanal is available for purchase for $989 USD.

]]> Caraway Extract https://affygility.com/oel/caraway-extract.html Mon, 29 Jun 2026 09:26:55 -0600 oel-fastrac-79490254 Affygility Solutions Caraway (Carum carvi L), also known as meadow cumin, is an herbaceous plant in the Apiaceae family. Caraway is native to western Asia and Europe but also grows in North America, Germany, Holland, Russia, Tunisia, Pakistan, Spain, and Scandinavia. Its fruits, often mistaken for seeds, have been used since ancient times for their benefits and characteristic aroma. Caraway extract is the extract from the dried seeds of Carum carvi. In northern and eastern Europe, caraway seeds are often used in rye and Irish soda breads, as well as cheese, liqueurs, cakes, and baked fruit dishes. Caraway extract is used in traditional medicine to aid digestion and to help stimulate appetite, to help relieve digestive spasms and indigestion, and to help relieve flatulent dyspepsia. Caraway has also been used traditionally as a remedy for menstrual cramps, poor appetite, bronchitis, laryngitis, and to promote milk excretion and weight loss. Caraway seeds, extracts, and oils can be found in carminative, laxative, and stomachic preparations. They have been used as a flavoring agent to mask unpleasant taste.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Caraway Extract is available for purchase for $1,399 USD.

]]> Olive Leaf Extract https://affygility.com/oel/olive-leaf-extract.html Mon, 29 Jun 2026 09:26:53 -0600 oel-fastrac-79490253 Affygility Solutions Olive leaf extract (OLE) is used in herbal medicine for its antihypertensive and diuretic actions. It has also been used in traditional medicine for healing malaria and the associated fever and to regulate body temperature. The extract has been found to exhibit strong antimicrobial properties against viruses, bacteria, yeast, and parasites. Olive leaf extract (OLE) also has numerous cardiovascular benefits, some hypoglycemic activity, and possesses antioxidant activity. It may also have cardiovascular benefits, improve blood lipids, and reduce inflammation. A standardized OLE has been used to improve postmenopausal concerns (such as bone loss, joint discomfort, and blood lipid imbalance) in women. The Olea europaea (olive)-derived ingredients are also reported to be used in cosmetics as skin-conditioning agents (emollient, humectant, or miscellaneous).

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Olive Leaf Extract is available for purchase for $1,399 USD.

]]> Doxribtimine https://affygility.com/oel/doxribtimine.html Wed, 24 Jun 2026 07:57:27 -0600 oel-fastrac-79489760 Affygility Solutions Doxribtimine, also known as 2'-deoxythymidine, thymidine, and deoxythymidine (dT), is a naturally occurring deoxyribonucleoside that is a crucial component of the deoxyribonucleic acid (DNA) salvage pathway and a building block for DNA synthesis Doxribtimine in combination with doxecitine is indicated for the treatment of thymidine kinase 2 deficiency (TK2d) in adults and pediatric patients with an age of symptom onset on or before 12 years of age.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Doxribtimine is available for purchase for $989 USD.

]]> Medazepam https://affygility.com/oel/medazepam.html Wed, 24 Jun 2026 07:57:25 -0600 oel-fastrac-79489759 Affygility Solutions Please note, this OEL/ADE monograph also applies to Medazepam hydrochloride (CAS RN 2898-11-5).Medazepam is a long-acting benzodiazepine used for its sedative and anxiolytic properties. Medazepam is indicated for the treatment of acute and chronic states of tension, agitation, and anxiety, as in physical reactions occurring due to psychological burdens.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Medazepam is available for purchase for $989 USD.

]]> Doxecitine https://affygility.com/oel/doxecitine.html Wed, 24 Jun 2026 07:57:22 -0600 oel-fastrac-79489758 Affygility Solutions Please note, this OEL/ADE monograph also applies to Doxecitine hydrochloride (CAS RN 3992-42-5).Doxecitine (also reported as deoxycytidine, d4C, or dC) is a synthetic form of the naturally occurring pyrimidine deoxyribonucleoside deoxycytidine. It is an essential component of the deoxyribonucleotide pool required for deoxyribonucleic acid (DNA) synthesis and repair. Doxecitine is currently approved and marketed as a fixed-dose combination therapy with thymidine (also known as doxribtimine, deoxythymidine, and dT). Doxecitine in combination with doxribtimine is indicated for the treatment of thymidine kinase 2 deficiency (TK2d) in adults and pediatric patients with an age of symptom onset on or before 12 years.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Doxecitine is available for purchase for $989 USD.

]]> Propolis Extract https://affygility.com/oel/propolis-extract.html Mon, 22 Jun 2026 09:05:47 -0600 oel-fastrac-79489399 Affygility Solutions Propolis is a honeybee product believed to have antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Raw propolis has been used in folk medicine since ancient times. In modern times, it is a starting raw material for manufacturing various extracts that can be used as active pharmaceutical ingredients. Among the biological activities of propolis extract, antimicrobial effects have been widely reported. Ethanolic extracts of propolis have been found to be effective against a broad range of bacteria, especially against gram-positive bacteria species. Propolis extract has been used as a nutritional supplement and in preparations for coughs, mouth disorders, and skin disorders. It has been used as an ointment for the relief of symptoms of herpes labialis. It is often found in topical formulations used to soothe minor skin irritations. Propolis extract has also been used in cosmetics and varnishes.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Propolis Extract is available for purchase for $1,399 USD.

]]> Tisotumab Vedotin https://affygility.com/oel/tisotumab-vedotin.html Mon, 22 Jun 2026 09:05:44 -0600 oel-fastrac-79489398 Affygility Solutions Tisotumab vedotin is an ADC comprised of an anti-TF human IgG1-kappa antibody conjugated to MMAE, a microtubule-disrupting agent, via a protease-cleavable vc linker. Tisotumab vedotin is indicated for the treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on chemotherapy or after chemotherapy.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Tisotumab Vedotin is available for purchase for $989 USD.

]]> Enfortumab Vedotin https://affygility.com/oel/enfortumab-vedotin.html Sat, 13 Jun 2026 10:35:08 -0600 oel-fastrac-79488082 Affygility Solutions Enfortumab vedotin is an ADC comprised of a fully human mAb and the microtubuledisrupting chemotherapeutic agent MMAE used in the treatment of advanced or metastatic urothelial cancer (mUC). Enfortumab vedotin, in combination with pembrolizumab or pembrolizumab and berahyaluronidase alfa-pmph as a neoadjuvant treatment and then continued after cystectomy as adjuvant treatment, is indicated for the treatment of adult patients with muscle invasive bladder cancer (MIBC) who are ineligible for cisplatin-containing chemotherapy. The combination therapy is also indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer. Enfortumab vedotin, as a single agent, is indicated for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor and platinum-containing chemotherapy or patients who are ineligible for cisplatincontaining chemotherapy and have previously received one or more prior lines of therapy.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Enfortumab Vedotin is available for purchase for $989 USD.

]]> Centella asiatica Extract https://affygility.com/oel/centella-asiatica-extract.html Sat, 13 Jun 2026 10:35:05 -0600 oel-fastrac-79488081 Affygility Solutions The herb Centella asiatica has been used in traditional Asian medicine for many years, especially for treating dermatological conditions, including small wounds, scratches, and burns, and as a hypertrophic wound-healing agent and an anti-inflammatory agent, particularly in eczema. However, gotu kola, Centella asiatica extract, and an ointment that contains Centella asiatica extract (Madecassol® ointment) are not Food and Drug Administration (FDA)-approved drug products. Centella asiatica extract is indicated for the treatment of first-degree burns, radiation burns, skin ulcers, and second-degree burns. Additionally, it is used for the symptomatic treatment of itching as a combination product with neomycin and for the therapy and treatment of damaged skin as a combination product with adenosine and acetyl hexapeptide-3. It is indicated for symptoms of venous insufficiency and capillary fragility, such as heavy legs, swelling, and edema in the lower limbs. The Centella asiatica preparations used in conventional medicine are available as tablets and drops for oral administration, as ointments, cream, gel, shampoo, and powder for topical administration, as injections for subcutaneous (SC) and intramuscular (IM) administration, and as external or internal homeopathic preparations.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Centella asiatica Extract is available for purchase for $1,399 USD.

]]> Polatuzumab Vedotin https://affygility.com/oel/polatuzumab-vedotin.html Sat, 13 Jun 2026 10:35:03 -0600 oel-fastrac-79488080 Affygility Solutions Polatuzumab vedotin is a CD79b-directed ADC that delivers MMAE, an antimitotic agent, to cancer cells. Polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) is indicated for the treatment of adult patients with previously untreated large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), high-grade B-cell lymphoma, Epstein-Barr virus-positive (EBV+) DLBCL NOS, and T-cell/histiocyte rich LBCL. Polatuzumab vedotin in combination with bendamustine and rituximab is indicated for the treatment of adult patients with relapsed or refractory diffuse large Bcell lymphoma (R/R DLBCL) NOS who are not eligible for autologous stem cell transplant and have received at least one prior therapy.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Polatuzumab Vedotin is available for purchase for $989 USD.

]]> Willow Bark Extract https://affygility.com/oel/willow-bark-extract.html Sat, 13 Jun 2026 10:35:00 -0600 oel-fastrac-79488079 Affygility Solutions Willow bark extract, also known as Salix bark extract, contains variable amounts of tannin and salicin, which has antipyretic and analgesic actions similar to those of aspirin. Willow bark extract has been used in traditional medicine for the treatment of fever, pain, and inflammation. It was once used as a bitter. Willow bark has traditionally also been used for muscular and arthroidal rheumatism with inflammation and pain, influenza, respiratory catarrh, gouty arthritis, ankylosing spondylitis, and specifically for rheumatoid arthritis and other systemic connective tissue disorders characterized by inflammatory changes. Willow bark extract can be used in cosmetics for skin-soothing benefits.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Willow Bark Extract is available for purchase for $1,399 USD.

]]> Baxdrostat https://affygility.com/oel/baxdrostat.html Sat, 13 Jun 2026 10:34:58 -0600 oel-fastrac-79488078 Affygility Solutions Baxdrostat (CIN-107, RO6836191) is an orally bioavailable, highly selective, first-in-class small-molecule aldosterone synthase inhibitor (ASI) used in combination with other antihypertensive medications for the treatment of inadequately controlled hypertension in adults.

Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

The OEL Fastrac monograph for Baxdrostat is available for purchase for $989 USD.

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