Sodium sulfoxylate formaldehyde (also known as rongalite) is the sodium salt form of formaldehydesulfoxylate, also known as hydroxymethanesulfinic acid. It was originally developed as a treatment for mercury poisoning but was found to be of limited value. Currently, it is widely used in organic synthesis. It can be used as a reducing agent for elemental selenium and tellurium, diselenides, α‐halo ketones, and aromatic aldehydes. It yields symmetrical sulfones with primary halides and with Michael acceptors. Sodium sulfoxylate formaldehyde is a water-soluble antioxidant and is generally used as the dihydrate. It is used as an excipient in the formulation of injection products at a level of up to 0.1% w/v (weight by volume) in the final preparation administered to the patient.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Formaldehydesulfoxylate, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.