Guanosine is a purine nucleoside with important functions in cell metabolism and a protective role in response to degenerative disease or injury thought to have neuroprotective properties. It is release in the brain under physiological conditions and during pathological events, reducing neuroinflammation, oxidative stress, excitotoxicity, and exerts trophic effects in neuronal and glial cells. Guanosine is a purine nucleoside in which guanine is linked to a ribofuranose ring by a beta- N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate, cyclic guanosine monophosphate, guanosine diphosphate (GDP), and guanosine triphosphate, which are factors in signal transduction pathways. The exact mechanism of action by which guanosine exert its neuroprotective properties remains to be fully elucidated but studies have shown that the biological effects are unrelated to direct G-proteins modulations but associated with the modulation of the glutamatergic and adenosinergic systems, trophic effects on neural cells and anti-apoptotic activity.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Guanosine, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.