Please note, this OEL/ADE monograph also applies to Histamine hydrochloride (CAS RN 55-36-7), Histamine dihydrochloride (CAS RN 56-92-8), Histamine phosphate (CAS RN 51-74-1), and Histamine bisphosphate monohydrate (CAS RN 23297-93-0). Histamine is a member of the class of imidazoles. It is a depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function, for asthma diagnosis, and as positive skin test control in evaluation of immediate hypersensitivity testing. Histamine dihydrochloride is used in combination with interleukin (IL)-2 (an oncologic medicine) as maintenance treatment in adults with acute myeloid leukemia (AML), a type of cancer affecting the white disease after the first course of treatment). Histamine is also an ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Histamine, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.