Horse chestnut seed extract (HCSE) is from the plant Aesculus hippocastanum L. Escin (also known as aescin, CAS# 6805-41-0) is the primary component of HCSE. It is a mixture of triterpene saponins present in alpha and beta forms, distinguished by their different levels of water solubility and melting points. Escin is indicated in adults for the oral treatment of chronic venous insufficiency and its associated symptoms, which include swelling of the lower limbs, varices, pain (generalized), feelings of weight of the lower limbs, itching, feelings of tension and cramps in the calves. Escin formulations are available as tablets and topical gel. It is marketed under the trade names Reparil®, Venocin® and Venitan® among others. Generic formulations are available.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Horse Chestnut Seed Extract, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.