Please note, this OEL/ADE monograph also applies to hydrocortisone acetate (CAS RN 50-03-3), hydrocortisone probutate (CAS RN 72590-77-3), hydrocortisone butyrate 119 mg (CAS 13609-67-1), hydrocortisone cypionate (CAS RN 508-99-6), hydrocortisone hydrogen succinate (CAS RN 2203-97-6; monohydrate CAS 83784- 20-7), hydrocortisone sodium phosphate (CAS RN 6000-74-4), hydrocortisone sodium succinate (CAS RN 125-04-2), and hydrocortisone valerate (CAS RN 57524-89-7). Cortisol is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through glycogenolysis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. It also decreases bone formation. During pregnancy, increased production of cortisol between weeks 30 and 32 initiates production of fetal lung surfactant to promote maturation of the lungs. Various synthetic forms of cortisol are used to treat a variety of diseases.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Hydrocortisone, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.