Please note, this OEL/ADE monograph also applies to ivermectin B1a (CAS RN 71827-03-7). Ivermectin is an orally bioavailable macrocyclic lactone derived from Streptomyces avermitilis, with antiparasitic and potential antiviral activities. Administered topically, ivermectin cream is indicated for the treatment of inflammatory lesions associated with rosacea. An over the counter ivermectin lotion is commercially available and indicated for the topical treatment of head lice infestations in patients ≥ 6 months of age. Orally administered ivermectin is indicated as a broad-spectrum antiparasitic for the treatment of intestinal strongyloidiasis caused by Strongyloides stercoralis and onchocerciasis caused by Onchocerca volvulus. Systemic ivermectin therapy is used internationally for the treatment of various tropical diseases including filariasis, cutaneous larva migrans, and Loa loa infection, among others.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Ivermectin, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.