Please note, this OEL/ADE monograph also applies to lidocaine parent (CAS RN 137-58-6) and lidocaine monohydrate (CAS RN 6108-05-0). Lidocaine hydrochloride (HCl), also known as lignocaine, is an amide type local anesthetic that is administered by topical application and by various parenteral administrations. Lidocaine blocks both initiation and conduction of nerve impulses by decreasing ionic flux through the neuronal membrane by blocking sodium channels, which results in local anesthesia. The mechanism by which lidocaine depresses arrhythmias may be its ability to depress conduction in ischemic myocardium (heart with low blood supply), rather than to improve conduction or to suppress the normal or abnormal automaticity.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL/ADE monograph for Lidocaine hydrochloride, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.