Magnesium hydroxide, Mg(OH)2, is indicated for use as an antacid or as a laxative depending on the administered dose. Following ingestion of 0.5 – 1.5 g (in adults), the hydroxide ions in magnesium hydroxide will combined with acidic H+ ions of hydrochloric acid made by the stomach. This combination neutralizes stomach acid, forming magnesium chloride and water. Following ingestion of 2-5 g (in adults), magnesium hydroxide acts as a laxative in the colon. This occurs due to the majority of magnesium hydroxide not being absorbed in the intestinal tract. It creates an osmotic effect to draw water into the gut from surrounding tissues, which softens feces and increases the volume of the intraluminal feces. These effects stimulate intestinal motility and induce the urge to defecate.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
To order an OEL monograph for this compound, just click the ADD TO CART button.
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.