Maytansine and its derivatives (named as maytansinoids in general) are members of the ansamycins superfamily and contain 19-member macrocyclic lactams attached to a chlorinated benzene. Maytansine was originally isolated from the Ethiopian shrub Maytenus ovatus and exerts extremely high antimitotic potency. Maytansinoids are microtubule-targeting agents that share the same binding site with vinca and function by depolymerizing microtubules and arresting cells in the mitosis stage. Synthetic maytansine derivatives have been synthesized that possess 100-fold to 1000-fold increases in potency over drug maytansinoids (DMs) while also including modifications to enable conjugation to an antibody (antibody-drug conjugates (ADCs)). The form of ADC significantly increases the therapeutic window of maytansinoids compared to the free drugs, enabling the usage of an otherwise highly toxic drug in cancer treatments.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Maytansine, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.