Please note, this OEL/ADE monograph also applies to meclizine dihydrochloride (CAS RN 1104-22-9). Meclizine is used in the treatment of vertigo, motion sickness, nausea during pregnancy and radiation sickness. Meclizine is a histamine antagonist. It depresses labyrinth excitability and conduction in vestibular-cerebellar pathways. It is an H-1 derivative that possesses anticholinergic, antiemetic, antispasmodic, central nervous system depressant and local anesthetic properties.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Meclizine, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.