Please note, this OEL/ADE monograph also applies to mepivacaine hydrochloride (CAS RN 1722-62-9). Mepivacaine is indicated for use as a local anesthetic to produce local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks. Mepivacaine is also indicated in veterinary medicine for intra-articular and epidural anesthesia in horses. Mepivacaine is a local anesthetic that acts by stabilizing the neuronal membrane and preventing the initiation and transmission of nerve impulses, thereby effecting local anesthesia. It has been suggested that mepivacaine increases the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. This occurs by mepivacaine binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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