Please note, this OEL/ADE monograph also applies to methohexital sodium (CAS RN 309-36-4). Methohexital a short-acting barbiturate used as an intravenous anesthetic of short duration for induction of anesthesia. Methohexital binds at a distinct binding site associated with a Cl-ionopore at the GABAA receptor, increasing the duration of time for which the Cl-ionopore is open. The postsynaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Methohexital, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.