Methylene blue (also known as methylthioninium chloride) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. The intravenous (IV) form of methylene blue is approved by the United States (US) Food and Drug Administration (FDA) for the treatment of pediatric patients and adult patients with acquired methemoglobinemia. Historically, it had been widely used in Africa to treat malaria, but it disappeared when chloroquine and other drugs entered the market. Its use as a urinary tract antiseptic has also been investigated. Methylene blue is also an investigational drug that has been shown in early clinical trials to be an inhibitor of tau protein aggregation and, therefore, the drug is of potential interest for the treatment of patients with Alzheimer's disease. Finally, methylene blue has been investigated for the treatment of ifosfamide-induced encephalopathy.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Methylene blue, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.