Metyrosine is indicated for pheochromocytoma, for preoperative preparation for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignancy. Metyrosine reduces catecholamine biosynthesis up to 80% by blocking tyrosine hydroxylase activity in converting tyrosine to dihydroxyphenylalanine (DOPA), which is the initial and rate-limiting step. Endogenous levels and urinary excretion of catecholamines and their metabolites are decreased in patients with pheochromocytoma, resulting in reduced blood pressure.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), and to obtain the following information:
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Affygility Solutions’s OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.