Please note, this OEL/ADE monograph also applies to naphazoline nitrate (CAS RN 5144-52-5) and naphazoline hydrochloride (CAS RN 550-99-2). Naphazoline is an adrenergic vasoconstrictor agent indicated for the treatment of nasal congestion and inflammation of the eye and eyelid. Naphazoline binds to peripheral alpha-adrenergic receptors at the site of action (the eye or nose) causing vasoconstriction. Naphazoline causes the release of norepinephrine in sympathetic nerves leading to binding to alpha-adrenergic receptors and vasoconstriction.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Naphazoline, just click the ADD TO CART button.
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.