Nimesulide is used for the treatment of pain and fever associated with osteoarthritis, rheumatoid arthritis and primary dysmenorrhea. It is not marketed in the United States, but is widely marketed around the world under many trade names. Nimesulide weakly inhibits prostaglandin synthesis and may exert its effects by several mechanisms including inhibiting the release of oxidants from neutrophils and histamine release. Based on in vitro data it may also inhibit release of enzymes which breakdown proteins and block metalloproteinase activity of cartilage cells in joints.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
To order an OEL/ADE monograph for Nimesulide, just click the ADD TO CART button.
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Not the compound you were looking for? You can search the OEL Fastrac catalog to find more available compounds.
Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.