Oxalic acid, the simplest dicarboxylic acid, is a potentially toxic chemical which is synthesized commercially and is also naturally present as a salt in many plants. It forms two series of salts. The first is a neutral, soluble species (with sodium, iron, lithium, or potassium) and the second is an insoluble acid species (with calcium or magnesium). Oxalic acid is a relatively strong acid, and forms a white, dihydrate precipitate. It may be encountered in industry and at home in cleaning and bleaching agents. Oxalic acid occurs naturally in plants and vegetables such as wood sorrel, rhubarb, and spinach. Alkali extraction of sawdust and the metabolism of many molds will also produce oxalic acid. It is manufactured by the reaction of carbon monoxide and sodium hydroxide or the reaction of sodium formate and sodium hydroxide or sodium formate and sodium carbonate. Oxalic acid is used in paint removers, stain removers and varnish removers, rust removers and ink stain removers, and in ceramics. It is used in general metal cleaning and equipment cleaning, wood cleaning, process engraving, rare-earth processing, printing, and dying, bleaching, textile finishing, chemical synthesis, making glucose from starch, leather tanning, and photography. It is also used in the manufacture of oxalates, and in the rubber manufacturing, lithographic, pharmaceutical, and paper industries, as a laboratory reagent, purifying agent, stripping agent, reducing agent, as a condensing agent in organic chemistry, as a chemical intermediate, as a catalyst, and for purifying methanol, decolorizing crude glycerol, and for stabilizing hydrocyanic acid.
Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.
OEL Fastrac monographs are a cost-effective and convenient way to meet the requirements for PDEs (ADEs) contained in the EMA Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities (EMA/CHMP/CVMP/SWP/169430/2012), as well as PIC/S and ANVISA requirements, and to obtain the following information:
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Affygility Solutions’ OEL Fastrac service is an user-friendly system that enables us to make confident decisions and focus on moving the compound safely through our facility. We can quickly access the database to determine if a new drug is within the OEL Fastrac library, and if so, immediately download a detailed OEL banding report. The OEL Fastrac system has been a helpful tool in our overall EH&S program.